Fab-based bispecific antibody formats with robust biophysical properties and biological activity

A myriad of innovative bispecific antibody (BsAb) platforms have been reported. Most require significant protein engineering to be viable from a development and manufacturing perspective. Single-chain variable fragments (scFvs) and diabodies that consist only of antibody variable domains have been u...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Wu, Xiufeng, Sereno, Arlene J, Huang, Flora, Lewis, Steven M, Lieu, Ricky L, Weldon, Caroline, Torres, Carina, Fine, Cody, Batt, Micheal A, Fitchett, Jonathan R, Glasebrook, Andrew L, Kuhlman, Brian, Demarest, Stephen J
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622572/
https://ncbi.nlm.nih.gov/pubmed/25774965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1022694
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