Computationally Designed Bispecific Antibodies Using Negative State Repertoires

A challenge in the structure-based design of specificity is modeling the negative states, i.e. the complexes that you do not want to form. This is a difficult problem because mutations predicted to destabilize the negative state might be accommodated by small conformational rearrangements. To overco...

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Vydáno v:Structure
Hlavní autoři: Leaver-Fay, Andrew, Froning, Karen J., Atwell, Shane, Aldaz, Hector, Pustilnik, Anna, Lu, Frances, Huang, Flora, Yuan, Richard, Hassanali, Saleema, Chamberlain, Aaron K., Fitchett, Jonathan R, Demarest, Stephen J., Kuhlman, Brian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866497/
https://ncbi.nlm.nih.gov/pubmed/26996964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.02.013
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