Computationally Designed Bispecific Antibodies Using Negative State Repertoires

A challenge in the structure-based design of specificity is modeling the negative states, i.e. the complexes that you do not want to form. This is a difficult problem because mutations predicted to destabilize the negative state might be accommodated by small conformational rearrangements. To overco...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Structure
Asıl Yazarlar: Leaver-Fay, Andrew, Froning, Karen J., Atwell, Shane, Aldaz, Hector, Pustilnik, Anna, Lu, Frances, Huang, Flora, Yuan, Richard, Hassanali, Saleema, Chamberlain, Aaron K., Fitchett, Jonathan R, Demarest, Stephen J., Kuhlman, Brian
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4866497/
https://ncbi.nlm.nih.gov/pubmed/26996964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.02.013
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller