Computational design of a specific heavy chain/κ light chain interface for expressing fully IgG bispecific antibodies

The use of bispecific antibodies (BsAbs) to treat human diseases is on the rise. Increasingly complex and powerful therapeutic mechanisms made possible by BsAbs are spurring innovation of novel BsAb formats and methods for their production. The long‐lived in vivo pharmacokinetics, optimal biophysica...

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Publicado no:Protein Sci
Main Authors: Froning, K. J., Leaver‐Fay, A., Wu, X., Phan, S., Gao, L., Huang, F., Pustilnik, A., Bacica, M., Houlihan, K., Chai, Q., Fitchett, J. R., Hendle, J., Kuhlman, B., Demarest, S. J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606552/
https://ncbi.nlm.nih.gov/pubmed/28726352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3240
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