Dichotomous impact of affinity on the function of T cell engaging bispecific antibodies

BACKGROUND: Bispecific T cell engagers represent the majority of bispecific antibodies (BsAbs) entering the clinic to treat metastatic cancer. The ability to apply these agents safely and efficaciously in the clinic, particularly for solid tumors, has been challenging. Many preclinical studies have...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Poussin, Mathilde, Sereno, Arlene, Wu, Xiufeng, Huang, Flora, Manro, Jason, Cao, Shanshan, Carpenito, Carmine, Glasebrook, Andrew, Powell Jr, Daniel J, Demarest, Stephen J
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Clinical/Translational Cancer Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276301/
https://ncbi.nlm.nih.gov/pubmed/34253637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002444
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