Site-specific antibody-drug conjugation through an engineered glycotransferase and a chemically reactive sugar

Conjugation of small molecule drugs to specific sites on the antibody molecule has been increasingly used for the generation of relatively homogenous preparations of antibody-drug conjugates (ADCs) with physicochemical properties similar or identical to those of the naked antibody. Previously a meth...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Zhu, Zhongyu, Ramakrishnan, Boopathy, Li, Jinyu, Wang, Yanping, Feng, Yang, Prabakaran, Ponraj, Colantonio, Simona, Dyba, Marzena A, Qasba, Pradman K, Dimitrov, Dimiter S
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622437/
https://ncbi.nlm.nih.gov/pubmed/25517304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.29889
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