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Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma
Recent studies have identified that constitutively active phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling is an important feature of osteosarcoma, where it promotes cell proliferation, survival, and chemo-resistance. Here, we studied the therapeutic potential...
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Опубликовано в: : | Cancer Biol Ther |
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Главные авторы: | , , , , , |
Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
Taylor & Francis
2015
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4622008/ https://ncbi.nlm.nih.gov/pubmed/25869769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1017155 |
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