Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 Has a Therapeutic Potential and Sensitizes Cisplatin in Nasopharyngeal Carcinoma

Phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin inhibitor (mTOR) pathway is often constitutively activated in human tumor cells and thus has been considered as a promising drug target. To ascertain a therapeutical approach of nasopharyngeal carcinoma (NPC), we hypothesized NVP-BEZ...

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Bibliographic Details
Main Authors: Yang, Fen, Qian, Xiao-Jun, Qin, Wei, Deng, Rong, Wu, Xiao-Qi, Qin, Juan, Feng, Gong-Kan, Zhu, Xiao-Feng
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606339/
https://ncbi.nlm.nih.gov/pubmed/23533654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059879
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