Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma

Recent studies have identified that constitutively active phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling is an important feature of osteosarcoma, where it promotes cell proliferation, survival, and chemo-resistance. Here, we studied the therapeutic potential...

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Vydáno v:Cancer Biol Ther
Hlavní autoři: Zhu, Yun-Rong, Min, Han, Fang, Jian-Feng, Zhou, Feng, Deng, Xiong-Wei, Zhang, Yun-Qing
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622008/
https://ncbi.nlm.nih.gov/pubmed/25869769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1017155
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