Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hH(V)1

Part of the “signature sequence” that defines the voltage-gated proton channel (H(V)1) is a tryptophan residue adjacent to the second Arg in the S4 transmembrane helix: RxWRxxR, which is perfectly conserved in all high confidence H(V)1 genes. Replacing Trp(207) in human H(V)1 (hH(V)1) with Ala, Ser,...

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Vydáno v:J Gen Physiol
Hlavní autoři: Cherny, Vladimir V., Morgan, Deri, Musset, Boris, Chaves, Gustavo, Smith, Susan M.E., DeCoursey, Thomas E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2015
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621752/
https://ncbi.nlm.nih.gov/pubmed/26458876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511456
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