Peregrination of the selectivity filter delineates the pore of the human voltage-gated proton channel hH(V)1

Extraordinary selectivity is crucial to all proton-conducting molecules, including the human voltage-gated proton channel (hH(V)1), because the proton concentration is >10(6) times lower than that of other cations. Here we use “selectivity filter scanning” to elucidate the molecular requirements...

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Detalhes bibliográficos
Main Authors: Morgan, Deri, Musset, Boris, Kulleperuma, Kethika, Smith, Susan M.E., Rajan, Sindhu, Cherny, Vladimir V., Pomès, Régis, DeCoursey, Thomas E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840923/
https://ncbi.nlm.nih.gov/pubmed/24218398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311045
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