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Hydrophobic gasket mutation produces gating pore currents in closed human voltage-gated proton channels

The hydrophobic gasket (HG), a ring of hydrophobic amino acids in the voltage-sensing domain of most voltage-gated ion channels, forms a constriction between internal and external aqueous vestibules. Cationic Arg or Lys side chains lining the S4 helix move through this “gating pore” when the channel...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Banh, Richard, Cherny, Vladimir V., Morgan, Deri, Musset, Boris, Thomas, Sarah, Kulleperuma, Kethika, Smith, Susan M. E., Pomès, Régis, DeCoursey, Thomas E.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754559/
https://ncbi.nlm.nih.gov/pubmed/31462498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905462116
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