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Tryptophan 207 is crucial to the unique properties of the human voltage-gated proton channel, hH(V)1
Part of the “signature sequence” that defines the voltage-gated proton channel (H(V)1) is a tryptophan residue adjacent to the second Arg in the S4 transmembrane helix: RxWRxxR, which is perfectly conserved in all high confidence H(V)1 genes. Replacing Trp(207) in human H(V)1 (hH(V)1) with Ala, Ser,...
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| Veröffentlicht in: | J Gen Physiol |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4621752/ https://ncbi.nlm.nih.gov/pubmed/26458876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201511456 |
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