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Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

The transporters for norepinephrine and dopamine (NET and DAT, respectively) constitute the molecular targets for recreational drugs and therapeutics used in the treatment of psychiatric disorders. Despite a strikingly similar amino acid sequence and predicted topology between these transporters, so...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Andersen, Jacob, Ringsted, Kristoffer B., Bang-Andersen, Benny, Strømgaard, Kristian, Kristensen, Anders S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621520/
https://ncbi.nlm.nih.gov/pubmed/26503701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15650
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