Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

The transporters for norepinephrine and dopamine (NET and DAT, respectively) constitute the molecular targets for recreational drugs and therapeutics used in the treatment of psychiatric disorders. Despite a strikingly similar amino acid sequence and predicted topology between these transporters, so...

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Published in:Sci Rep
Main Authors: Andersen, Jacob, Ringsted, Kristoffer B., Bang-Andersen, Benny, Strømgaard, Kristian, Kristensen, Anders S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621520/
https://ncbi.nlm.nih.gov/pubmed/26503701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15650
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