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FACT disrupts nucleosome structure by binding H2A-H2B with conserved peptide motifs

FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that the H2A-H2B binding activity that is central to FACT function resides in short acidic regions near the C-termini of each subunit. Mutations throughout these regions impact binding and cause correlated phenotypes t...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Kemble, David J., McCullough, Laura L., Whitby, Frank G., Formosa, Tim, Hill, Christopher P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4620744/
https://ncbi.nlm.nih.gov/pubmed/26455391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.09.008
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