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FACT disrupts nucleosome structure by binding H2A-H2B with conserved peptide motifs
FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that the H2A-H2B binding activity that is central to FACT function resides in short acidic regions near the C-termini of each subunit. Mutations throughout these regions impact binding and cause correlated phenotypes t...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4620744/ https://ncbi.nlm.nih.gov/pubmed/26455391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.09.008 |
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