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Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT

The histone chaperone FACT is an essential and abundant heterodimer found in all eukaryotes. Here we report a crystal structure of the middle domain of the large subunit of FACT (Spt16-M) to reveal a double pleckstrin homology architecture. This structure was found previously in the Pob3-M domain of...

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Detalhes bibliográficos
Main Authors: Kemble, David J., Whitby, Frank G., Robinson, Howard, McCullough, Laura L., Formosa, Tim, Hill, Christopher P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624403/
https://ncbi.nlm.nih.gov/pubmed/23417676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.451369
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