How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective

The use of in vitro metabolism data to predict human clearance has become more significant in the current prediction of large scale drug clearance for all the drugs. The relevant information (in vitro metabolism data and in vivo human clearance values) of thirty-five drugs that satisfied the entry c...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Wang, Lei, Chiang, ChienWei, Liang, Hong, Wu, Hengyi, Feng, Weixing, Quinney, Sara K., Li, Jin, Li, Lang
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619875/
https://ncbi.nlm.nih.gov/pubmed/26539530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/857327
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