Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine

BACKGROUND: For over two decades, a racemic mixture of oxamniquine (OXA) was administered to patients infected by Schistosoma mansoni, but whether one or both enantiomers exert antischistosomal activity was unknown. Recently, a ~30 kDa S. m ansoni sulfotransferase (SmSULT) was identified as the targ...

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Foilsithe in:PLoS Negl Trop Dis
Main Authors: Taylor, Alexander B., Pica-Mattoccia, Livia, Polcaro, Chiara M., Donati, Enrica, Cao, Xiaohang, Basso, Annalisa, Guidi, Alessandra, Rugel, Anastasia R., Holloway, Stephen P., Anderson, Timothy J. C., Hart, P. John, Cioli, Donato, LoVerde, Philip T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618941/
https://ncbi.nlm.nih.gov/pubmed/26485649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004132
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