Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner.

Kedarcidin chromophore is a 9-membered enediyne, recently isolated from an actinomycete strain. In vivo studies show this molecule to be extremely active against P388 leukemia and B16 melanoma. Cytotoxicity assays on the HCT116 colon carcinoma cell line result in an IC50 value of 1 nM. In vitro expe...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Zein, N, Colson, K L, Leet, J E, Schroeder, D R, Solomon, W, Doyle, T W, Casazza, A M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46188/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8464895/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.7.2822
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