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Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner.

Kedarcidin chromophore is a 9-membered enediyne, recently isolated from an actinomycete strain. In vivo studies show this molecule to be extremely active against P388 leukemia and B16 melanoma. Cytotoxicity assays on the HCT116 colon carcinoma cell line result in an IC50 value of 1 nM. In vitro expe...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zein, N, Colson, K L, Leet, J E, Schroeder, D R, Solomon, W, Doyle, T W, Casazza, A M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46188/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8464895/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.7.2822
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