Kedarcidin chromophore: an enediyne that cleaves DNA in a sequence-specific manner.

Kedarcidin chromophore is a 9-membered enediyne, recently isolated from an actinomycete strain. In vivo studies show this molecule to be extremely active against P388 leukemia and B16 melanoma. Cytotoxicity assays on the HCT116 colon carcinoma cell line result in an IC50 value of 1 nM. In vitro expe...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Zein, N, Colson, K L, Leet, J E, Schroeder, D R, Solomon, W, Doyle, T W, Casazza, A M
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1993
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46188/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8464895/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.7.2822
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