Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation.

B1(dsFv)-PE33 is a recombinant immunotoxin composed of a mutant form of Pseudomonas exotoxin (PE) that does not need proteolytic activation and a disulfide-stabilized Fv fragment of the anti-Lewis(y) monoclonal antibody B1, which recognizes a carbohydrate epitope on human carcinoma cells. In this mo...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kuan, C T, Pastan, I
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40014/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8577771/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.3.974
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