Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation.
B1(dsFv)-PE33 is a recombinant immunotoxin composed of a mutant form of Pseudomonas exotoxin (PE) that does not need proteolytic activation and a disulfide-stabilized Fv fragment of the anti-Lewis(y) monoclonal antibody B1, which recognizes a carbohydrate epitope on human carcinoma cells. In this mo...
Guardat en:
| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1996
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40014/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8577771/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.3.974 |
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