Mechanisms by which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Anti-proliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells In Vitro

BACKGROUND: Synthetic 6,7-annulated-4-substituted indole compounds, which elicit interesting antitumor effects in murine L1210 leukemia cells, were tested for their ability to inhibit human HL-60 tumor cell proliferation, disrupt mitosis and cytokinesis, and interfere with tubulin and actin polymeri...

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Bibliografski detalji
Izdano u:Anticancer Res
Glavni autori: PERCHELLET, JEAN-PIERRE H., PERCHELLET, ELISABETH M., SINGH, CHINGAKHAM RANJIT, MONNETT, MEGHAN T., STUDER, ELIZABETH R., THORNTON, PAUL D., BROWN, NEIL, HILL, DAVID, NEUENSWANDER, BEN, LUSHINGTON, GERALD H., SANTINI, CONRAD, BUSZEK, KEITH R.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618554/
https://ncbi.nlm.nih.gov/pubmed/24692693
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