Application of 6,7-Indole Aryne Cycloaddition and Pd(0)-Catalyzed Suzuki-Miyaura and Buchwald-Hartwig Cross-Coupling Reactions for the Preparation of Annulated Indole Libraries

The construction of an unprecedented class of an indole-based library, namely, a 6,7-annulated-4-substituted 93-member indole library, using a strategic combination of 6,7-indolyne cycloaddition and cross-coupling reactions under both Suzuki-Miyaura and Buchwald-Hartwig conditions is described. This...

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Main Authors: Thornton, Paul D., Brown, Neil, Hill, David, Neuenswander, Ben, Lushington, Gerald H., Santini, Conrad, Buszek, Keith R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959986/
https://ncbi.nlm.nih.gov/pubmed/21668016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co2000289
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