Mechanisms by which Synthetic 6,7-Annulated-4-substituted Indole Compounds with Anti-proliferative Activity Disrupt Mitosis and Block Cytokinesis in Human HL-60 Tumor Cells In Vitro

BACKGROUND: Synthetic 6,7-annulated-4-substituted indole compounds, which elicit interesting antitumor effects in murine L1210 leukemia cells, were tested for their ability to inhibit human HL-60 tumor cell proliferation, disrupt mitosis and cytokinesis, and interfere with tubulin and actin polymeri...

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Publicado no:Anticancer Res
Main Authors: PERCHELLET, JEAN-PIERRE H., PERCHELLET, ELISABETH M., SINGH, CHINGAKHAM RANJIT, MONNETT, MEGHAN T., STUDER, ELIZABETH R., THORNTON, PAUL D., BROWN, NEIL, HILL, DAVID, NEUENSWANDER, BEN, LUSHINGTON, GERALD H., SANTINI, CONRAD, BUSZEK, KEITH R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618554/
https://ncbi.nlm.nih.gov/pubmed/24692693
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