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Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency
Here we show that bivalent domains and chromosome architecture for bivalent genes are dynamically regulated during the cell cycle in human pluripotent cells. Central to this is the transient increase in H3K4-trimethylation at developmental genes during G1, thereby creating a “window of opportunity”...
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| Publicado en: | Stem Cell Reports |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4618451/ https://ncbi.nlm.nih.gov/pubmed/26278042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.07.005 |
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