Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency

Here we show that bivalent domains and chromosome architecture for bivalent genes are dynamically regulated during the cell cycle in human pluripotent cells. Central to this is the transient increase in H3K4-trimethylation at developmental genes during G1, thereby creating a “window of opportunity”...

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Udgivet i:Stem Cell Reports
Main Authors: Singh, Amar M., Sun, Yuhua, Li, Li, Zhang, Wenjuan, Wu, Tianming, Zhao, Shaying, Qin, Zhaohui, Dalton, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618451/
https://ncbi.nlm.nih.gov/pubmed/26278042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2015.07.005
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