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Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH using hyperpolarized [1,2-(13)C(2)]pyruvate in vivo
(13)C MR spectroscopy studies performed on hearts ex vivo and in vivo following perfusion of pre-polarized [1-(13)C]pyruvate have shown that changes in pyruvate dehydrogenase (PDH) flux may be monitored non-invasively. However, to allow investigation of Krebs cycle metabolism, the (13)C label must b...
שמור ב:
| הוצא לאור ב: | NMR Biomed |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2011
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4618301/ https://ncbi.nlm.nih.gov/pubmed/21774012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.1749 |
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