Direct Measurement of Cardiac Na(+) Channel Conformations Reveals Molecular Pathologiesof Inherited Mutations

BACKGROUND: Dysregulation of voltage-gated cardiac Na(+) channels (Na(V)1.5) by inherited mutations, disease-linked remodeling, and drugs causes arrhythmias. The molecular mechanisms whereby the Na(V)1.5 voltage-sensing domains (VSDs) are perturbed to pathologically or therapeutically modulate Na(+)...

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Detalhes bibliográficos
Publicado no:Circ Arrhythm Electrophysiol
Main Authors: Varga, Zoltan, Zhu, Wandi, Schubert, Angela R., Pardieck, Jennifer L., Krumholz, Arie, Hsu, Eric J., Zaydman, Mark A., Cui, Jianmin, Silva, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618166/
https://ncbi.nlm.nih.gov/pubmed/26283144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.115.003155
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