Mechanisms of noncovalent β subunit regulation of Na(V) channel gating

Voltage-gated Na(+) (Na(V)) channels comprise a macromolecular complex whose components tailor channel function. Key components are the non-covalently bound β1 and β3 subunits that regulate channel gating, expression, and pharmacology. Here, we probe the molecular basis of this regulation by applyin...

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Bibliografiske detaljer
Udgivet i:J Gen Physiol
Main Authors: Zhu, Wandi, Voelker, Taylor L., Varga, Zoltan, Schubert, Angela R., Nerbonne, Jeanne M., Silva, Jonathan R.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560778/
https://ncbi.nlm.nih.gov/pubmed/28720590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711802
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