Regulation of Na(+) channel inactivation by the DIII and DIV voltage-sensing domains

Functional eukaryotic voltage-gated Na(+) (Na(V)) channels comprise four domains (DI–DIV), each containing six membrane-spanning segments (S1–S6). Voltage sensing is accomplished by the first four membrane-spanning segments (S1–S4), which together form a voltage-sensing domain (VSD). A critical Na(V...

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Udgivet i:J Gen Physiol
Main Authors: Hsu, Eric J., Zhu, Wandi, Schubert, Angela R., Voelker, Taylor, Varga, Zoltan, Silva, Jonathan R.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339511/
https://ncbi.nlm.nih.gov/pubmed/28232510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611678
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