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Negative charges in the DIII–DIV linker of human skeletal muscle Na(+) channels regulate deactivation gating

Charge reversing, neutralizing and substituting mutations at D1309 and EE1314,15 in the DIII–DIV linker of the human skeletal muscle sodium channel hNa(v)1.4 were constructed and expressed in Xenopus oocytes. The effects of these mutations on conductance, inactivation and deactivation were determine...

詳細記述

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書誌詳細
主要な著者: Groome, James R, Fujimoto, Esther, Ruben, Peter C
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Science Inc 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2342797/
https://ncbi.nlm.nih.gov/pubmed/12588896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.033084
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