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Negative charges in the DIII–DIV linker of human skeletal muscle Na(+) channels regulate deactivation gating
Charge reversing, neutralizing and substituting mutations at D1309 and EE1314,15 in the DIII–DIV linker of the human skeletal muscle sodium channel hNa(v)1.4 were constructed and expressed in Xenopus oocytes. The effects of these mutations on conductance, inactivation and deactivation were determine...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2342797/ https://ncbi.nlm.nih.gov/pubmed/12588896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.033084 |
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