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Outer and central charged residues in DIVS4 of skeletal muscle sodium channels have differing roles in deactivation.

We tested the effects of charge-neutralizing mutations of the eight arginine residues in DIVS4 of the rat skeletal muscle sodium channel (rNa(V)1.4) on deactivation gating from the open and inactivated states. We hypothesized that neutralization of outer or central charges would accelerate the I-to-...

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Autors principals: Groome, James, Fujimoto, Esther, Walter, Lisa, Ruben, Peter
Format: Artigo
Idioma:Inglês
Publicat: 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1301932/
https://ncbi.nlm.nih.gov/pubmed/11867446
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