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Negative charges in the DIII–DIV linker of human skeletal muscle Na(+) channels regulate deactivation gating

Charge reversing, neutralizing and substituting mutations at D1309 and EE1314,15 in the DIII–DIV linker of the human skeletal muscle sodium channel hNa(v)1.4 were constructed and expressed in Xenopus oocytes. The effects of these mutations on conductance, inactivation and deactivation were determine...

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Autors principals: Groome, James R, Fujimoto, Esther, Ruben, Peter C
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2342797/
https://ncbi.nlm.nih.gov/pubmed/12588896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2002.033084
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