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Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling

Notch receptors direct the differentiation of T helper (T(H)) cell subsets, but their influence on regulatory T (T(reg)) cell responses is obscure. We here report that lineage-specific deletion of components of the Notch pathway enhanced T(reg) cell-mediated suppression of T(H)1 responses, and prote...

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Pubblicato in:Nat Immunol
Autori principali: Charbonnier, Louis-Marie, Wang, Sen, Georgiev, Peter, Sefik, Esen, Chatila, Talal A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618075/
https://ncbi.nlm.nih.gov/pubmed/26437242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3288
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