Regulatory T cell reprogramming towards a Th2 cell-like lineage impairs oral tolerance and promotes food allergy

Oral immunotherapy has had limited success in establishing tolerance in food allergy, reflecting failure to elicit an effective regulatory T (Treg) cell response. We show that disease-susceptible mice (Il4ra(F709)) with enhanced IL-4 receptor (IL-4R) signaling exhibited STAT6-dependent impaired gene...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Rivas, Magali Noval, Burton, Oliver T., Wise, Petra, Charbonnier, Louis-Marie, Georgiev, Peter, Oettgen, Hans C., Rachid, Rima, Chatila, Talal
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366316/
https://ncbi.nlm.nih.gov/pubmed/25769611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.02.004
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