Regulatory T cell reprogramming towards a Th2 cell-like lineage impairs oral tolerance and promotes food allergy

Oral immunotherapy has had limited success in establishing tolerance in food allergy, reflecting failure to elicit an effective regulatory T (Treg) cell response. We show that disease-susceptible mice (Il4ra(F709)) with enhanced IL-4 receptor (IL-4R) signaling exhibited STAT6-dependent impaired gene...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Immunity
Hlavní autoři: Rivas, Magali Noval, Burton, Oliver T., Wise, Petra, Charbonnier, Louis-Marie, Georgiev, Peter, Oettgen, Hans C., Rachid, Rima, Chatila, Talal
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366316/
https://ncbi.nlm.nih.gov/pubmed/25769611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.02.004
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky