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Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and the Recessive A2V Familial Alzheimer's Disease Mutation

Oligomeric states of the amyloid β-protein (Aβ) appear to be causally related to Alzheimer’s disease (AD). Recently, two familial mutations in the amyloid precursor protein gene have been described, both resulting in amino acid substitutions at Ala2 (A2) within Aβ. An A2V mutation causes autosomal r...

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Detalles Bibliográficos
Publicado en:ACS Chem Neurosci
Main Authors: Zheng, Xueyun, Liu, Deyu, Roychaudhuri, Robin, Teplow, David B., Bowers, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618051/
https://ncbi.nlm.nih.gov/pubmed/26244608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00171
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