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Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and the Recessive A2V Familial Alzheimer's Disease Mutation
Oligomeric states of the amyloid β-protein (Aβ) appear to be causally related to Alzheimer’s disease (AD). Recently, two familial mutations in the amyloid precursor protein gene have been described, both resulting in amino acid substitutions at Ala2 (A2) within Aβ. An A2V mutation causes autosomal r...
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| Опубликовано в: : | ACS Chem Neurosci |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4618051/ https://ncbi.nlm.nih.gov/pubmed/26244608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.5b00171 |
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