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Amyloid β-protein assembly and Alzheimer’s disease: Dodecamers of Aβ42, but not of Aβ40, seed fibril formation
Evidence suggests that oligomers of the 42-residue form of the amyloid β-protein (Aβ), Aβ42 play a critical role in the etiology of Alzheimer’s disease (AD). Here we use high resolution atomic force microscopy to directly image populations of small oligomers of Aβ42 that occur at the earliest stages...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4849547/ https://ncbi.nlm.nih.gov/pubmed/26839237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b11913 |
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