Llwytho...

Amyloid β-protein assembly and Alzheimer’s disease: Dodecamers of Aβ42, but not of Aβ40, seed fibril formation

Evidence suggests that oligomers of the 42-residue form of the amyloid β-protein (Aβ), Aβ42 play a critical role in the etiology of Alzheimer’s disease (AD). Here we use high resolution atomic force microscopy to directly image populations of small oligomers of Aβ42 that occur at the earliest stages...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Economou, Nicholas J., Giammona, Maxwell J., Do, Thanh D., Zheng, Xueyun, Teplow, David B., Buratto, Steven K., Bowers, Michael T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849547/
https://ncbi.nlm.nih.gov/pubmed/26839237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b11913
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