Amyloid β-protein assembly and Alzheimer’s disease: Dodecamers of Aβ42, but not of Aβ40, seed fibril formation

Evidence suggests that oligomers of the 42-residue form of the amyloid β-protein (Aβ), Aβ42 play a critical role in the etiology of Alzheimer’s disease (AD). Here we use high resolution atomic force microscopy to directly image populations of small oligomers of Aβ42 that occur at the earliest stages...

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Detaylı Bibliyografya
Yayımlandı:J Am Chem Soc
Asıl Yazarlar: Economou, Nicholas J., Giammona, Maxwell J., Do, Thanh D., Zheng, Xueyun, Teplow, David B., Buratto, Steven K., Bowers, Michael T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849547/
https://ncbi.nlm.nih.gov/pubmed/26839237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b11913
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