A Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation

BACKGROUND: Heterozygous human NKX2-5 homeodomain (DNA binding domain) missense mutations are highly penetrant for varied congenital heart defects, including progressive atrioventricular block (AVB) requiring pacemaker implantation. We recently replicated this genetic defect in a murine knock-in mod...

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Vydáno v:Circ Arrhythm Electrophysiol
Hlavní autoři: Chowdhury, Rajib, Ashraf, Hassan, Melanson, Michelle, Tanada, Yohei, Nguyen, Minh, Silberbach, G. Michael, Wakimoto, Hiroko, Benson, D. Woodrow, Anderson, Robert H., Kasahara, Hideko
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618020/
https://ncbi.nlm.nih.gov/pubmed/26226998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.115.002720
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