Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein

A DNA nonbinding mutant of the NK2 class homeoprotein Nkx2.5 dominantly inhibits cardiogenesis in Xenopus embryos, causing a small heart to develop or blocking heart formation entirely. Recently, ten heterozygous CSX/NKX2.5 homeoprotein mutations were identified in patients with congenital atriovent...

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Hlavní autoři: Kasahara, Hideko, Wakimoto, Hiroko, Liu, Margaret, Maguire, Colin T., Converso, Kimber L., Shioi, Tetsuo, Huang, Weei-Yuarn, Manning, Warren J., Paul, David, Lawitts, Joel, Berul, Charles I., Izumo, Seigo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2001
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC203028/
https://ncbi.nlm.nih.gov/pubmed/11457872
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