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Crystallization and preliminary X-ray analysis of the NKX2.5 homeodomain in complex with DNA

As part of an effort to elucidate the molecular basis for the pathogenesis of NKX2.5 mutations in congenital heart disease using X-ray crystallography, the NKX2.5 homeodomain has been crystallized in complex with a specific DNA element, the −242 promoter region of atrial natriuretic factor. Crystals...

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Detalhes bibliográficos
Main Authors: Genis, Caroli, Scone, Peyton, Kasahara, Hideko, Nam, Hyun-Joo
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581709/
https://ncbi.nlm.nih.gov/pubmed/18997347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309108033447
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