Crystal Structure of the Human NKX2.5 Homeodomain in Complex with DNA Target

[Image: see text] NKX2.5 is a homeodomain containing transcription factor regulating cardiac formation and function, and its mutations are linked to congenital heart disease. Here we provide the first report of the crystal structure of the NKX2.5 homeodomain in complex with double-stranded DNA of it...

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Bibliographic Details
Main Authors: Pradhan, Lagnajeet, Genis, Caroli, Scone, Peyton, Weinberg, Ellen O., Kasahara, Hideko, Nam, Hyun-Joo
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448007/
https://ncbi.nlm.nih.gov/pubmed/22849347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300849c
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