Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD)

INTRODUCTION: We previously reported that alveolar macrophages from patients with chronic obstructive pulmonary disease (COPD) are defective in their ability to phagocytose apoptotic cells, with a similar defect in response to cigarette smoke. The exact mechanisms for this defect are unknown. Sphing...

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Udgivet i:PLoS One
Main Authors: Barnawi, Jameel, Tran, Hai, Jersmann, Hubertus, Pitson, Stuart, Roscioli, Eugene, Hodge, Greg, Meech, Robyn, Haberberger, Rainer, Hodge, Sandra
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617901/
https://ncbi.nlm.nih.gov/pubmed/26485657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122771
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