Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD

INTRODUCTION: We have previously established a link between impaired phagocytic capacity and deregulated S1P signaling in alveolar macrophages from COPD subjects. We hypothesize that this defect may include a disruption of epithelial-macrophage crosstalk via Spns2-mediated intercellular S1P signalin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tran, Hai B., Jersmann, Hubertus, Truong, Tung Thanh, Hamon, Rhys, Roscioli, Eugene, Ween, Miranda, Pitman, Melissa R., Pitson, Stuart M., Hodge, Greg, Reynolds, Paul N., Hodge, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675303/
https://ncbi.nlm.nih.gov/pubmed/29112690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179577
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