Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs for the treatment of epileptic seizures. Although it is well known that the doses of VPA and its plasma concentrations are highly correlated, the plasma concentrations do not correlate well with the therapeutic effects of t...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Nakashima, Hiroo, Oniki, Kentaro, Nishimura, Miki, Ogusu, Naoki, Shimomasuda, Masatsugu, Ono, Tatsumasa, Matsuda, Kazuki, Yasui-Furukori, Norio, Nakagawa, Kazuko, Ishitsu, Takateru, Saruwatari, Junji
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617862/
https://ncbi.nlm.nih.gov/pubmed/26484865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141266
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