Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs for the treatment of epileptic seizures. Although it is well known that the doses of VPA and its plasma concentrations are highly correlated, the plasma concentrations do not correlate well with the therapeutic effects of t...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Nakashima, Hiroo, Oniki, Kentaro, Nishimura, Miki, Ogusu, Naoki, Shimomasuda, Masatsugu, Ono, Tatsumasa, Matsuda, Kazuki, Yasui-Furukori, Norio, Nakagawa, Kazuko, Ishitsu, Takateru, Saruwatari, Junji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617862/
https://ncbi.nlm.nih.gov/pubmed/26484865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141266
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