Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs for the treatment of epileptic seizures. Although it is well known that the doses of VPA and its plasma concentrations are highly correlated, the plasma concentrations do not correlate well with the therapeutic effects of t...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Nakashima, Hiroo, Oniki, Kentaro, Nishimura, Miki, Ogusu, Naoki, Shimomasuda, Masatsugu, Ono, Tatsumasa, Matsuda, Kazuki, Yasui-Furukori, Norio, Nakagawa, Kazuko, Ishitsu, Takateru, Saruwatari, Junji
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617862/
https://ncbi.nlm.nih.gov/pubmed/26484865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141266
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