Chromatin architecture of the Pitx2 locus requires CTCF and Pitx2 dependent asymmetry that mirrors embryonic gut laterality

Expression of Pitx2 on the left side of the embryo patterns left-right (LR) organs including the dorsal mesentery (DM), whose asymmetric cell behavior directs gut looping. Despite the importance of organ laterality, chromatin-level regulation of Pitx2 remains undefined. Here we show that genes immed...

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Udgivet i:Cell Rep
Main Authors: Welsh, Ian C., Kwak, Hojoong, Chen, Frances L., Werner, Melissa, Shopland, Lindsay S., Danko, Charles G., Lis, John T., Zhang, Min, Martin, James F., Kurpios, Natasza A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617833/
https://ncbi.nlm.nih.gov/pubmed/26411685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.075
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