Crown ethers attenuate aggregation of Amyloid beta of Alzheimer’s disease

The stagnant state of drug development for Alzheimer’s disease demands new approaches for seeking promising candidates. In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) peptide by crown ethers could inhibit its aggregation. To specifically target Aβs, a conjugate of Pi...

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Veröffentlicht in:Chem Commun (Camb)
Hauptverfasser: Tian, Yanli, Zhang, Xueli, Li, Yuyan, Shoup, Timothy M., Teng, Xin, Elmaleh, David R., Moore, Anna, Ran, Chongzhao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4617529/
https://ncbi.nlm.nih.gov/pubmed/25372154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc06029f
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